טוען...

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

The precise molecular mechanism of action and targets through which thalidomide and related immunomodulatory drugs (IMiDs) exert their antitumor effects remains unclear. We investigated the role of cereblon (CRBN), a primary teratogenic target of thalidomide, in the antimyeloma activity of IMiDs. CR...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Van Wier, Scott, Chang, Xiu-Bao, Bjorklund, Chad C., Fonseca, Rafael, Bergsagel, P. Leif, Orlowski, Robert Z., Stewart, A. Keith
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208291/
https://ncbi.nlm.nih.gov/pubmed/21860026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-356063
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