Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). Using 2 different methodologies, we identified 244 CRBN binding proteins and established relevance to MM biology by changes in their abundance after exposure to lenalidomide. Proteins most reproducibly binding CRB...

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Detalhes bibliográficos
Main Authors: Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Kortuem, K. Martin, Bruins, Laura A., Schmidt, Jessica E., Chang, Xiu-Bao, Langlais, Paul, Luo, Moulun, Jedlowski, Patrick, LaPlant, Betsy, Laumann, Kristina, Fonseca, Rafael, Bergsagel, P. Leif, Mikhael, Joseph, Lacy, Martha, Champion, Mia D., Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110660/
https://ncbi.nlm.nih.gov/pubmed/24914135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-557819
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