The clinical significance of cereblon expression in multiple myeloma

Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). We demonstrate here that no patient with very low CRBN expression responded to IMiD plus dexamethasone therapy. In 53 refractory MM patients treated with pomalidomide and dexamethasone, CRBN levels predict for dec...

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Bibliografski detalji
Glavni autori: Schuster, Steven R., Kortuem, K. Martin, Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Ahmann, Greg, Kumar, Shaji, Rajkumar, S. Vincent, Mikhael, Joseph, LaPlant, Betsy, Champion, Mia D., Laumann, Kristina, Barlogie, Bart, Fonseca, Rafael, Bergsagel, P. Leif, Lacy, Martha, Stewart, A. Keith
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905958/
https://ncbi.nlm.nih.gov/pubmed/24129344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.08.015
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