The clinical significance of cereblon expression in multiple myeloma

Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). We demonstrate here that no patient with very low CRBN expression responded to IMiD plus dexamethasone therapy. In 53 refractory MM patients treated with pomalidomide and dexamethasone, CRBN levels predict for dec...

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Detalhes bibliográficos
Main Authors: Schuster, Steven R., Kortuem, K. Martin, Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Ahmann, Greg, Kumar, Shaji, Rajkumar, S. Vincent, Mikhael, Joseph, LaPlant, Betsy, Champion, Mia D., Laumann, Kristina, Barlogie, Bart, Fonseca, Rafael, Bergsagel, P. Leif, Lacy, Martha, Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905958/
https://ncbi.nlm.nih.gov/pubmed/24129344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.08.015
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