RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

The molecular target(s) cooperating with proteasome inhibition in multiple myeloma (MM) remain unknown. We therefore measured proliferation in MM cells transfected with 13 984 small interfering RNAs in the absence or presence of increasing concentrations of bortezomib. We identified 37 genes, which...

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Detalhes bibliográficos
Main Authors: Zhu, Yuan Xiao, Tiedemann, Rodger, Shi, Chang-Xin, Yin, Holly, Schmidt, Jessica E., Bruins, Laura A., Keats, Jonathan J., Braggio, Esteban, Sereduk, Chris, Mousses, Spyro, Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083298/
https://ncbi.nlm.nih.gov/pubmed/21289309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-304022
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