RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

The molecular target(s) cooperating with proteasome inhibition in multiple myeloma (MM) remain unknown. We therefore measured proliferation in MM cells transfected with 13 984 small interfering RNAs in the absence or presence of increasing concentrations of bortezomib. We identified 37 genes, which...

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Bibliografiske detaljer
Main Authors: Zhu, Yuan Xiao, Tiedemann, Rodger, Shi, Chang-Xin, Yin, Holly, Schmidt, Jessica E., Bruins, Laura A., Keats, Jonathan J., Braggio, Esteban, Sereduk, Chris, Mousses, Spyro, Stewart, A. Keith
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083298/
https://ncbi.nlm.nih.gov/pubmed/21289309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-304022
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