Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Knockout and transgenic studies in mice demonstrate that normal somatic tissues redundantly express 3 cyclin D proteins, whereas tumor cells seem dependent on a single overexpressed cyclin D. Thus, selective suppression of the individual cyclin D deregulated in a tumor represents a biologically vali...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tiedemann, Rodger E., Mao, Xinliang, Shi, Chang-Xin, Zhu, Yuan Xiao, Palmer, Stephen E., Sebag, Michael, Marler, Ron, Chesi, Marta, Fonseca, Rafael, Bergsagel, P. Leif, Schimmer, Aaron D., Stewart, A. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323188/
https://ncbi.nlm.nih.gov/pubmed/18431519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34149
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados