AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies

By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, we have achieved sporadic, AID-dependent MYC activation in germinal center B-cells of Vk*MYC mice. Whereas control C57BL/6 mice develop benign monoclonal gammopathy with age, all Vk*MYC mice progress t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chesi, Marta, Robbiani, Davide F., Sebag, Michael, Chng, Wee Joo, Affer, Maurizio, Tiedemann, Rodger, Valdez, Riccardo, Palmer, Stephen E., Haas, Stephanie S., Stewart, A. Keith, Fonseca, Rafael, Kremer, Richard, Cattoretti, Giorgio, Bergsagel, P. Leif
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2255064/
https://ncbi.nlm.nih.gov/pubmed/18242516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.01.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados