Promiscuous Rearrangements of the MYC Locus Hijack Enhancers and Super-Enhancers to Dysregulate MYC Expression in Multiple Myeloma

MYC locus rearrangements – often complex combinations of translocations, insertions, deletions, and inversions - in multiple myeloma (MM) were thought to be a late progression event, which often did not involve immunoglobulin genes. Yet germinal center activation of MYC expression has been reported...

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Autors principals: Affer, Maurizio, Chesi, Marta, Chen, Wei-Dong G., Keats, Jonathan J., Demchenko, Yulia N., Roschke, Anna V., Van Wier, Scott, Fonseca, Rafael, Bergsagel, P. Leif, Kuehl, W. Michael
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126852/
https://ncbi.nlm.nih.gov/pubmed/24518206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.70
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