Loss of FAM46C promotes cell survival in myeloma

FAM46C is one of the most recurrently mutated genes in multiple myeloma (MM), however its role in disease pathogenesis has not been determined. Here we demonstrate that wild type (WT) FAM46C overexpression induces substantial cytotoxicity in MM cells. In contrast, FAM46C mutations found in MM patien...

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Pubblicato in:Cancer Res
Autori principali: Zhu, Yuan Xiao, Shi, Chang-Xin, Bruins, Laura A., Jedlowski, Patrick, Wang, Xuewei, Kortüm, K. Martin, Luo, Moulun, Ahmann, Jonathan M., Braggio, Esteban, Stewart, A. Keith
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586597/
https://ncbi.nlm.nih.gov/pubmed/28619709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3011
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