Loss of FAM46C promotes cell survival in myeloma

FAM46C is one of the most recurrently mutated genes in multiple myeloma (MM), however its role in disease pathogenesis has not been determined. Here we demonstrate that wild type (WT) FAM46C overexpression induces substantial cytotoxicity in MM cells. In contrast, FAM46C mutations found in MM patien...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Zhu, Yuan Xiao, Shi, Chang-Xin, Bruins, Laura A., Jedlowski, Patrick, Wang, Xuewei, Kortüm, K. Martin, Luo, Moulun, Ahmann, Jonathan M., Braggio, Esteban, Stewart, A. Keith
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586597/
https://ncbi.nlm.nih.gov/pubmed/28619709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3011
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