Structural basis for the recognition of c-Src by its inactivator Csk

Por Levinson, Nicholas M., Seeliger, Markus A., Cole, Philip A., Kuriyan, John
Publicado em 2008

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Por Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S, Kuriyan, John, Daley, George Q
Publicado em 2008

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Por Foda, Zachariah H., Shan, Yibing, Kim, Eric T., Shaw, David E., Seeliger, Markus A.
Publicado no Nat Commun (2015)

Catalytic control in the EGF Receptor and its connection to general kinase regulatory mechanisms

Por Jura, Natalia, Zhang, Xuewu, Endres, Nicholas F., Seeliger, Markus A., Schindler, Thomas, Kuriyan, John
Publicado em 2011

Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

Por Georghiou, George, Kleiner, Ralph E., Pulkoski-Gross, Michael, Liu, David R., Seeliger, Markus A.
Publicado em 2012

Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src

Por Hari, Sanjay B., Perera, B. Gayani K., Ranjitkar, Pratistha, Seeliger, Markus A., Maly, Dustin J.
Publicado em 2013

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Por Tong, Michael, Pelton, Jeff G., Gill, Michelle L., Zhang, Weibing, Picart, Francis, Seeliger, Markus A.
Publicado no Nat Commun (2017)

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and IP(6) in mRNA export

Por Montpetit, Ben, Thomsen, Nathan D., Helmke, Kara J., Seeliger, Markus A., Berger, James M., Weis, Karsten
Publicado em 2011

How Does a Drug Molecule Find its Target Binding Site?

Por Shan, Yibing, Kim, Eric, Eastwood, Michael P., Dror, Ron O., Seeliger, Markus A., Shaw, David E.
Publicado em 2011

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

Por Seeliger, Markus A., Young, Matthew, Henderson, M. Nidanie, Pellicena, Patricia, King, David S., Falick, Arnold M., Kuriyan, John
Publicado em 2005

A novel in vitro CypD-mediated p53 aggregation assay suggests a model for mitochondrial permeability transition by chaperone systems

Por Lebedev, Ivan, Nemajerova, Alice, Foda, Zachariah H, Kornaj, Maja, Tong, Michael, Moll, Ute M., Seeliger, Markus A.
Publicado no J Mol Biol (2016)

Dynamically coupled residues within the SH2 domain of FYN are key to unlocking its activity

Por Huculeci, Radu, Cilia, Elisa, Lyczek, Agatha, Buts, Lieven, Houben, Klaartje, Seeliger, Markus A., van Nuland, Nico, Lenaerts, Tom
Publicado no Structure (2016)

What makes a kinase promiscuous for inhibitors?

Por Hanson, Sonya M., Georghiou, George, Thakur, Manish K., Miller, W. Todd, Rest, Joshua S., Chodera, John D., Seeliger, Markus A.
Publicado no Cell Chem Biol (2019)

Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations

Por Seeliger, Markus A., Ranjitkar, Pratistha, Kasap, Corynn, Shan, Yibing, Shaw, David E., Shah, Neil P., Kuriyan, John, Maly, Dustin J.
Publicado em 2009

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Por Maianti, Juan Pablo, Tan, Grace A., Vetere, Amedeo, Welsh, Amie J., Wagner, Bridget K., Seeliger, Markus A., Liu, David R.
Publicado no Nat Chem Biol (2019)

Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue

Por Muratore, Kathryn E., Seeliger, Markus A., Wang, Zhihong, Fomina, Dina, Neiswinger, Johnathan, Havranek, James J., Baker, David, Kuriyan, John, Cole, Philip A.
Publicado em 2009

A conserved protonation-dependent switch controls drug binding in the Abl kinase

Por Shan, Yibing, Seeliger, Markus A., Eastwood, Michael P., Frank, Filipp, Xu, Huafeng, Jensen, Morten Ø, Dror, Ron O., Kuriyan, John, Shaw, David E.
Publicado em 2009

N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor

Por Choi, Yongmun, Seeliger, Markus A., Panjarian, Shoghag B., Kim, Hakjoong, Deng, Xianming, Sim, Taebo, Couch, Brian, Koleske, Anthony J., Smithgall, Thomas E., Gray, Nathanael S.
Publicado em 2009

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions

Por Alford, Vincent M., Kamath, Anushree, Ren, Xiaodong, Kumar, Kunal, Gan, Qianwen, Awwa, Monaf, Tong, Michael, Seeliger, Markus A., Cao, Jian, Ojima, Iwao, Sampson, Nicole S.
Publicado no ACS Chem Biol (2017)

Tuning a Three Component Reaction For Trapping Kinase Substrate Complexes

Por Statsuk, Alexander V., Maly, Dustin J., Seeliger, Markus A., Fabian, Miles A., Biggs, William H., Lockhart, David J., Zarrinkar, Patrick P., Kuriyan, John, Shokat, Kevan M.
Publicado em 2008