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A conserved protonation-dependent switch controls drug binding in the Abl kinase
In many protein kinases, a characteristic conformational change (the “DFG flip”) connects catalytically active and inactive conformations. Many kinase inhibitors—including the cancer drug imatinib—selectively target a specific DFG conformation, but the function and mechanism of the flip remain uncle...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610013/ https://ncbi.nlm.nih.gov/pubmed/19109437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811223106 |
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