A conserved protonation-dependent switch controls drug binding in the Abl kinase

In many protein kinases, a characteristic conformational change (the “DFG flip”) connects catalytically active and inactive conformations. Many kinase inhibitors—including the cancer drug imatinib—selectively target a specific DFG conformation, but the function and mechanism of the flip remain uncle...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Shan, Yibing, Seeliger, Markus A., Eastwood, Michael P., Frank, Filipp, Xu, Huafeng, Jensen, Morten Ø, Dror, Ron O., Kuriyan, John, Shaw, David E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610013/
https://ncbi.nlm.nih.gov/pubmed/19109437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811223106
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller