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Dynamically coupled residues within the SH2 domain of FYN are key to unlocking its activity
Src kinase activity is controlled by various mechanisms, involving a coordinated movement of kinase and regulatory domains. Notwithstanding the extensive knowledge related to the backbone dynamics, little is known about the more subtle side-chain dynamics within the regulatory domains and their role...
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| Vydáno v: | Structure |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5093032/ https://ncbi.nlm.nih.gov/pubmed/27692963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.016 |
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