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Dynamically coupled residues within the SH2 domain of FYN are key to unlocking its activity

Src kinase activity is controlled by various mechanisms, involving a coordinated movement of kinase and regulatory domains. Notwithstanding the extensive knowledge related to the backbone dynamics, little is known about the more subtle side-chain dynamics within the regulatory domains and their role...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Structure
Egile Nagusiak: Huculeci, Radu, Cilia, Elisa, Lyczek, Agatha, Buts, Lieven, Houben, Klaartje, Seeliger, Markus A., van Nuland, Nico, Lenaerts, Tom
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093032/
https://ncbi.nlm.nih.gov/pubmed/27692963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.016
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