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Structural insights into the intertwined dimer of fyn SH2

Src homology 2 domains are interaction modules dedicated to the recognition of phosphotyrosine sites incorporated in numerous proteins found in intracellular signaling pathways. Here we provide for the first time structural insight into the dimerization of Fyn SH2 both in solution and in crystalline...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Huculeci, Radu, Garcia‐Pino, Abel, Buts, Lieven, Lenaerts, Tom, van Nuland, Nico
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815226/
https://ncbi.nlm.nih.gov/pubmed/26384592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2806
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