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Effect of pH and salt bridges on structural assembly: Molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain

The SH3 domain of Eps8 was previously found to form an intertwined, domain-swapped dimer. We report here a monomeric structure of the EPS8 SH3 domain obtained from crystals grown at low pH, as well as an improved domain-swapped dimer structure at 1.8 Å resolution. In the domain-swapped dimer the asy...

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Bibliographische Detailangaben
Hauptverfasser: Kishan, K.V. Radha, Newcomer, Marcia E., Rhodes, Thomas H., Guilliot, Stephen D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374198/
https://ncbi.nlm.nih.gov/pubmed/11316885
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