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pH driven conformational dynamics and dimer-to-monomer transition in DLC8

Dynein light chain protein, a part of the cytoplasmic motor assembly, is a homodimer at physiological pH and dissociates below pH 4.5 to a monomer. The dimer binds to a variety of cargo, whereas the monomer does not bind any of the target proteins. We report here the pH induced stepwise structural a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mohan, P.M. Krishna, Barve, Maneesha, Chatterjee, Amarnath, Hosur, Ramakrishna V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242461/
https://ncbi.nlm.nih.gov/pubmed/16385004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051854906
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