From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors

Src Homology 3 domains are ubiquitous small interaction modules known to act as docking sites and regulatory elements in a wide range of proteins. Prior experimental NMR work on the SH3 domain of Src showed that ligand binding induces long-range dynamic changes consistent with an induced fit mechani...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Zafra Ruano, Ana, Cilia, Elisa, Couceiro, José R., Ruiz Sanz, Javier, Schymkowitz, Joost, Rousseau, Frederic, Luque, Irene, Lenaerts, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877006/
https://ncbi.nlm.nih.gov/pubmed/27213566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004938
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