An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

We previously showed the existence of selective pressure against protein aggregation by the enrichment of aggregation-opposing ‘gatekeeper’ residues at strategic places along the sequence of proteins. Here we analyzed the relationship between protein lifetime and protein aggregation by combining exp...

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Autores principales: De Baets, Greet, Reumers, Joke, Delgado Blanco, Javier, Dopazo, Joaquin, Schymkowitz, Joost, Rousseau, Frederic
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121684/
https://ncbi.nlm.nih.gov/pubmed/21731483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002090
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