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Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations

BACKGROUND: Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and residue burial can be used to distinguish neutral variations and disease associate...

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Библиографические подробности
Главные авторы: Reumers, Joke, Schymkowitz, Joost, Rousseau, Fréderic
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745591/
https://ncbi.nlm.nih.gov/pubmed/19758473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S8-S9
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