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Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations
BACKGROUND: Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and residue burial can be used to distinguish neutral variations and disease associate...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745591/ https://ncbi.nlm.nih.gov/pubmed/19758473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S8-S9 |
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