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Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations

BACKGROUND: Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and residue burial can be used to distinguish neutral variations and disease associate...

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Bibliografische gegevens
Hoofdauteurs: Reumers, Joke, Schymkowitz, Joost, Rousseau, Fréderic
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745591/
https://ncbi.nlm.nih.gov/pubmed/19758473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S8-S9
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