Učitavanje...

Activation of tyrosine kinases by mutation of the gatekeeper threonine

Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the ‘gatekeeper’ threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth factor receptor-α and -β, and epidermal growth...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Azam, Mohammad, Seeliger, Markus A, Gray, Nathanael S, Kuriyan, John, Daley, George Q
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575426/
https://ncbi.nlm.nih.gov/pubmed/18794843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1486
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!