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Activation of tyrosine kinases by mutation of the gatekeeper threonine
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the ‘gatekeeper’ threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth factor receptor-α and -β, and epidermal growth...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575426/ https://ncbi.nlm.nih.gov/pubmed/18794843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1486 |
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