Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue

Protein tyrosine kinases are critical cell signaling enzymes. These enzymes have a highly conserved Arg residue in their catalytic loop which is present two residues or four residues downstream from an absolutely conserved Asp catalytic base. Prior studies on protein tyrosine kinases Csk and Src rev...

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Bibliografiske detaljer
Main Authors: Muratore, Kathryn E., Seeliger, Markus A., Wang, Zhihong, Fomina, Dina, Neiswinger, Johnathan, Havranek, James J., Baker, David, Kuriyan, John, Cole, Philip A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714740/
https://ncbi.nlm.nih.gov/pubmed/19260709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900057g
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