Identification of Targets of c-Src Tyrosine Kinase by Chemical Complementation and Phosphoproteomics

The cellular proto-oncogene c-Src is a nonreceptor tyrosine kinase involved in cell growth and cytoskeletal regulation. Despite being dysregulated in a variety of human cancers, its precise functions are not fully understood. Identification of the substrates of c-Src remains a major challenge, becau...

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Detalhes bibliográficos
Main Authors: Ferrando, Isabel Martinez, Chaerkady, Raghothama, Zhong, Jun, Molina, Henrik, Jacob, Harrys K.C., Herbst-Robinson, Katie, Dancy, Beverley M., Katju, Vikram, Bose, Ron, Zhang, Jin, Pandey, Akhilesh, Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412967/
https://ncbi.nlm.nih.gov/pubmed/22499769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.015750
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