Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response

Mutations in the Epidermal growth factor receptor (EGFR) kinase domain, such as the L858R missense mutation and deletions spanning the conserved sequence (747)LREA(750), are sensitive to tyrosine kinase inhibitors (TKIs). The gatekeeper site residue mutation, T790M accounts for around 60% of acquire...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Zhang, Xu, Maity, Tapan, Kashyap, Manoj K., Bansal, Mukesh, Venugopalan, Abhilash, Singh, Sahib, Awasthi, Shivangi, Marimuthu, Arivusudar, Charles Jacob, Harrys Kishore, Belkina, Natalya, Pitts, Stephanie, Cultraro, Constance M., Gao, Shaojian, Kirkali, Guldal, Biswas, Romi, Chaerkady, Raghothama, Califano, Andrea, Pandey, Akhilesh, Guha, Udayan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417828/
https://ncbi.nlm.nih.gov/pubmed/28331001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M117.067439
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