Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics

Mutations in the Epidermal growth factor receptor (EGFR) kinase domain occur in 10–30% of lung adenocarcinoma and are associated with tyrosine kinase inhibitor (TKI) sensitivity. We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung adenocarcinoma. W...

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Bibliografiske detaljer
Udgivet i:Proteomics
Main Authors: Zhang, Xu, Belkina, Natalya, Jacob, Harrys Kishore Charles, Maity, Tapan, Biswas, Romi, Venugopalan, Abhilash, Shaw, Patrick G., Kim, Min-Sik, Chaerkady, Raghothama, Pandey, Akhilesh, Guha, Udayan
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461560/
https://ncbi.nlm.nih.gov/pubmed/25404012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400315
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