Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue

Protein tyrosine kinases are critical cell signaling enzymes. These enzymes have a highly conserved Arg residue in their catalytic loop which is present two residues or four residues downstream from an absolutely conserved Asp catalytic base. Prior studies on protein tyrosine kinases Csk and Src rev...

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Bibliographic Details
Main Authors: Muratore, Kathryn E., Seeliger, Markus A., Wang, Zhihong, Fomina, Dina, Neiswinger, Johnathan, Havranek, James J., Baker, David, Kuriyan, John, Cole, Philip A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714740/
https://ncbi.nlm.nih.gov/pubmed/19260709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900057g
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