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Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue

Protein tyrosine kinases are critical cell signaling enzymes. These enzymes have a highly conserved Arg residue in their catalytic loop which is present two residues or four residues downstream from an absolutely conserved Asp catalytic base. Prior studies on protein tyrosine kinases Csk and Src rev...

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Detalhes bibliográficos
Main Authors: Muratore, Kathryn E., Seeliger, Markus A., Wang, Zhihong, Fomina, Dina, Neiswinger, Johnathan, Havranek, James J., Baker, David, Kuriyan, John, Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714740/
https://ncbi.nlm.nih.gov/pubmed/19260709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900057g
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