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N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor

Allosteric kinase inhibitors hold promise for revealing unique features of kinases that may not be apparent using conventional ATP-competitive inhibitors. Here we explore the activity of a previously reported allosteric inhibitor of BCR-Abl kinase, GNF-2, against two cellular isoforms of Abl tyrosin...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Choi, Yongmun, Seeliger, Markus A., Panjarian, Shoghag B., Kim, Hakjoong, Deng, Xianming, Sim, Taebo, Couch, Brian, Koleske, Anthony J., Smithgall, Thomas E., Gray, Nathanael S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781447/
https://ncbi.nlm.nih.gov/pubmed/19679652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026633
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