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N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor

Allosteric kinase inhibitors hold promise for revealing unique features of kinases that may not be apparent using conventional ATP-competitive inhibitors. Here we explore the activity of a previously reported allosteric inhibitor of BCR-Abl kinase, GNF-2, against two cellular isoforms of Abl tyrosin...

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Autores principales: Choi, Yongmun, Seeliger, Markus A., Panjarian, Shoghag B., Kim, Hakjoong, Deng, Xianming, Sim, Taebo, Couch, Brian, Koleske, Anthony J., Smithgall, Thomas E., Gray, Nathanael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781447/
https://ncbi.nlm.nih.gov/pubmed/19679652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026633
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