Expanding the Diversity of Allosteric Bcr-Abl Inhibitors

[Image: see text] Inhibition of Bcr-Abl kinase activity by imatinib for the treatment of chronic myeloid leukemia (CML) currently serves as the paradigm for targeting dominant oncogenes with small molecules. We recently reported the discovery of GNF-2 (1) and GNF-5 (2) as selective non-ATP competiti...

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Bibliografiske detaljer
Main Authors: Deng, Xianming, Okram, Barun, Ding, Qiang, Zhang, Jianming, Choi, Yongmun, Adrián, Francisco J., Wojciechowski, Amy, Zhang, Guobao, Che, Jianwei, Bursulaya, Badry, Cowan-Jacob, Sandra W., Rummel, Gabriele, Sim, Taebo, Gray, Nathanael S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951064/
https://ncbi.nlm.nih.gov/pubmed/20828158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100555f
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