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Broad Spectrum Alkynyl Inhibitors of T315I Bcr-Abl
A series of alkyne containing type II inhibitors with potent inhibitory activity of T315I Bcr-Abl has been identified. The most active compound 4 exhibits an EC(50) of less than 1 nM against wild-type Bcr-Abl and an EC(50) of 10 nM against T315I mutant but is broadly active against a number of other...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901992/ https://ncbi.nlm.nih.gov/pubmed/20541934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.043 |
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