High-throughput approaches to profile RNA-protein interactions

par Nechay, Misha, Kleiner, Ralph E.
Publié dans Curr Opin Chem Biol (2019)

YTHDF2 recognition of N(1)-methyladenosine (m(1)A)-modified RNA is associated with transcript destabilization

par Seo, Kyung W., Kleiner, Ralph E.
Publié dans ACS Chem Biol (2019)

Mechanisms of epitranscriptomic gene regulation

par Seo, Kyung W., Kleiner, Ralph E.
Publié dans Biopolymers (2020)

Cell- and polymerase-selective metabolic labeling of cellular RNA with 2’-azidocytidine

par Wang, Danyang, Zhang, Yu, Kleiner, Ralph E.
Publié dans J Am Chem Soc (2020)

Site-Specific Chemistry on the Microtubule Polymer

par Kleiner, Ralph E., Ti, Shih-Chieh, Kapoor, Tarun M.
Publié 2013

Small-Molecule Discovery from DNA-Encoded Chemical Libraries()

par Kleiner, Ralph E., Dumelin, Christoph E., Liu, David R.
Publié dans Chem Soc Rev (2011)

In vitro selection with a site-specifically modified RNA library reveals the binding preferences of N(6)-methyladenosine (m(6)A) reader proteins

par Arguello, A. Emilia, Leach, Robert W., Kleiner, Ralph E.
Publié dans Biochemistry (2019)

DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes

par Kleiner, Ralph E., Brudno, Yevgeny, Birnbaum, Michael E., Liu, David R.
Publié 2008

An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids

par Brudno, Yevgeny, Birnbaum, Michael E., Kleiner, Ralph E., Liu, David R.
Publié 2009

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

par Kleiner, Ralph E., Verma, Priyanka, Molloy, Kelly R., Chait, Brian T., Kapoor, Tarun M.
Publié dans Nat Chem Biol (2015)

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

par Kleiner, Ralph E., Dumelin, Christoph E., Tiu, Gerald C., Sakurai, Kaori, Liu, David R.
Publié 2010

Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

par Georghiou, George, Kleiner, Ralph E., Pulkoski-Gross, Michael, Liu, David R., Seeliger, Markus A.
Publié 2012

A chemical proteomics approach to reveal direct protein-protein interactions in living cells

par Kleiner, Ralph E., Hang, Lisa E., Molloy, Kelly R., Chait, Brian T., Kapoor, Tarun M.
Publié dans Cell Chem Biol (2017)

A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila

par Kan, Lijuan, Ott, Stanislav, Joseph, Brian, Park, Eun Sil, Dai, Wei, Kleiner, Ralph E., Claridge-Chang, Adam, Lai, Eric C.
Publié dans Nat Commun (2021)

Publisher Correction: A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila

par Kan, Lijuan, Ott, Stanislav, Joseph, Brian, Park, Eun Sil, Dai, Wei, Kleiner, Ralph E., Claridge-Chang, Adam, Lai, Eric C.
Publié dans Nat Commun (2021)

Mutations in human tubulin proximal to the kinesin binding site alter dynamic instability at microtubule plus- and minus-ends

par Ti, Shih-Chieh, Pamula, Melissa C., Howes, Stuart C., Duellberg, Christian, Cade, Nicholas I., Kleiner, Ralph E., Forth, Scott, Surrey, Thomas, Nogales, Eva, Kapoor, Tarun M.
Publié dans Dev Cell (2016)

Structural and biochemical basis for intracellular kinase inhibition by Src-specific peptidic macrocycles

par Aleem, Saadat, Georghiou, George, Kleiner, Ralph E., Guja, Kip, Craddock, Barbara P., Lyczek, Agatha, Chan, Alix I., Garcia-Diaz, Miguel, Miller, W. Todd, Liu, David R., Seeliger, Markus A.
Publié dans Cell Chem Biol (2016)

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

par Maianti, Juan Pablo, McFedries, Amanda, Foda, Zachariah H., Kleiner, Ralph E., Du, Xiu Quan, Leissring, Malcolm A., Tang, Wei-Jen, Charron, Maureen J., Seeliger, Markus A., Saghatelian, Alan, Liu, David R.
Publié 2014