In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

[Image: see text] DNA-templated organic synthesis enables the translation of DNA sequences into synthetic small-molecule libraries suitable for in vitro selection. Previously, we described the DNA-templated multistep synthesis of a 13 824-membered small-molecule macrocycle library. Here, we report t...

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Detaylı Bibliyografya
Asıl Yazarlar: Kleiner, Ralph E., Dumelin, Christoph E., Tiu, Gerald C., Sakurai, Kaori, Liu, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2010
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924185/
https://ncbi.nlm.nih.gov/pubmed/20681606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104903x
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