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Structural and biochemical basis for intracellular kinase inhibition by Src-specific peptidic macrocycles
Protein kinases are attractive therapeutic targets because their dysregulation underlies many diseases, including cancer. The high conservation of the kinase domain and the evolution of drug resistance, however, pose major challenges to the development of specific kinase inhibitors. We recently disc...
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| 發表在: | Cell Chem Biol |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5096457/ https://ncbi.nlm.nih.gov/pubmed/27593110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.07.017 |
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