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Structural basis of nonribosomal peptide macrocyclization in fungi

Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation lik...

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Bibliografski detalji
Izdano u:Nat Chem Biol
Glavni autori: Zhang, Jinru, Liu, Nicholas, Cacho, Ralph A., Gong, Zhou, Liu, Zhu, Qin, Wenming, Tang, Chun, Tang, Yi, Zhou, Jiahai
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110376/
https://ncbi.nlm.nih.gov/pubmed/27748753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2202
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