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Structural basis of nonribosomal peptide macrocyclization in fungi
Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation lik...
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| Publicado en: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110376/ https://ncbi.nlm.nih.gov/pubmed/27748753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2202 |
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