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Circular logic: Nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst

[Image: see text] A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rathe...

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Detalhes bibliográficos
Main Authors: McIntosh, John A., Robertson, Charles R., Agarwal, Vinayak, Nair, Satish K., Bulaj, Grzegorz W., Schmidt, Eric W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975588/
https://ncbi.nlm.nih.gov/pubmed/20961047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1067806
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