Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex

Yazar: Schulze-Gahmen, Ursula, Hurley, James H.
Yayımlandı Proc Natl Acad Sci U S A (2018)

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

Yazar: Schulze-Gahmen, Ursula, Lu, Huasong, Zhou, Qiang, Alber, Tom
Baskı/Yayın Bilgisi 2014

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

Yazar: Lu, Huasong, Li, Zichong, Zhang, Wei, Schulze-Gahmen, Ursula, Xue, Yuhua, Zhou, Qiang
Yayımlandı Nucleic Acids Res (2015)

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Yazar: Qi, Shiqian, Li, Zichong, Schulze-Gahmen, Ursula, Stjepanovic, Goran, Zhou, Qiang, Hurley, James H.
Yayımlandı Nat Commun (2017)

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Yazar: Schulze-Gahmen, Ursula, Upton, Heather, Birnberg, Andrew, Bao, Katherine, Chou, Seemay, Krogan, Nevan J, Zhou, Qiang, Alber, Tom
Baskı/Yayın Bilgisi 2013

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

Yazar: Lu, Huasong, Li, Zichong, Xue, Yuhua, Schulze-Gahmen, Ursula, Johnson, Jeffrey R., Krogan, Nevan J., Alber, Tom, Zhou, Qiang
Baskı/Yayın Bilgisi 2014

Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs

Yazar: Meyer, Nicole O., O’Donoghue, Anthony J., Schulze-Gahmen, Ursula, Ravalin, Matthew, Moss, Steven M., Winter, Michael B., Knudsen, Giselle M., Craik, Charles S.
Yayımlandı Anal Chem (2017)

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

Yazar: Schulze-Gahmen, Ursula, Echeverria, Ignacia, Stjepanovic, Goran, Bai, Yun, Lu, Huasong, Schneidman-Duhovny, Dina, Doudna, Jennifer A, Zhou, Qiang, Sali, Andrej, Hurley, James H
Yayımlandı eLife (2016)

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

Yazar: Chou, Seemay, Upton, Heather, Bao, Katherine, Schulze-Gahmen, Ursula, Samelson, Avi J., He, Nanhai, Nowak, Anna, Lu, Huasong, Krogan, Nevan J., Zhou, Qiang, Alber, Tom
Baskı/Yayın Bilgisi 2013

Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation

Yazar: Deng, Xianding, Garcia-Knight, Miguel A, Khalid, Mir M., Servellita, Venice, Wang, Candace, Morris, Mary Kate, Sotomayor-González, Alicia, Glasner, Dustin R, Reyes, Kevin R, Gliwa, Amelia S., Reddy, Nikitha P., Martin, Claudia Sanchez San, Federman, Scot, Cheng, Jing, Balcerek, Joanna, Taylor, Jordan, Streithorst, Jessica A, Miller, Steve, Kumar, G. Renuka, Sreekumar, Bharath, Chen, Pei-Yi, Schulze-Gahmen, Ursula, Taha, Taha Y., Hayashi, Jennifer, Simoneau, Camille R., McMahon, Sarah, Lidsky, Peter V., Xiao, Yinghong, Hemarajata, Peera, Green, Nicole M., Espinosa, Alex, Kath, Chantha, Haw, Monica, Bell, John, Hacker, Jill K., Hanson, Carl, Wadford, Debra A., Anaya, Carlos, Ferguson, Donna, Lareau, Liana F., Frankino, Phillip A., Shivram, Haridha, Wyman, Stacia K., Ott, Melanie, Andino, Raul, Chiu, Charles Y.
Yayımlandı medRxiv (2021)

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

Yazar: Deng, Xianding, Garcia-Knight, Miguel A., Khalid, Mir M., Servellita, Venice, Wang, Candace, Morris, Mary Kate, Sotomayor-González, Alicia, Glasner, Dustin R., Reyes, Kevin R., Gliwa, Amelia S., Reddy, Nikitha P., Sanchez San Martin, Claudia, Federman, Scot, Cheng, Jing, Balcerek, Joanna, Taylor, Jordan, Streithorst, Jessica A., Miller, Steve, Sreekumar, Bharath, Chen, Pei-Yi, Schulze-Gahmen, Ursula, Taha, Taha Y., Hayashi, Jennifer M., Simoneau, Camille R., Kumar, G. Renuka, McMahon, Sarah, Lidsky, Peter V., Xiao, Yinghong, Hemarajata, Peera, Green, Nicole M., Espinosa, Alex, Kath, Chantha, Haw, Monica, Bell, John, Hacker, Jill K., Hanson, Carl, Wadford, Debra A., Anaya, Carlos, Ferguson, Donna, Frankino, Phillip A., Shivram, Haridha, Lareau, Liana F., Wyman, Stacia K., Ott, Melanie, Andino, Raul, Chiu, Charles Y.
Yayımlandı Cell (2021)

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

Yazar: Schuller, Marion, Correy, Galen J., Gahbauer, Stefan, Fearon, Daren, Wu, Taiasean, Díaz, Roberto Efraín, Young, Iris D., Martins, Luan Carvalho, Smith, Dominique H., Schulze-Gahmen, Ursula, Owens, Tristan W., Deshpande, Ishan, Merz, Gregory E., Thwin, Aye C., Biel, Justin T., Peters, Jessica K., Moritz, Michelle, Herrera, Nadia, Kratochvil, Huong T., Aimon, Anthony, Bennett, James M., Neto, Jose Brandao, Cohen, Aina E., Dias, Alexandre, Douangamath, Alice, Dunnett, Louise, Fedorov, Oleg, Ferla, Matteo P., Fuchs, Martin, Gorrie-Stone, Tyler J., Holton, James M., Johnson, Michael G., Krojer, Tobias, Meigs, George, Powell, Ailsa J., Rangel, Victor L, Russi, Silvia, Skyner, Rachael E., Smith, Clyde A., Soares, Alexei S., Wierman, Jennifer L., Zhu, Kang, Jura, Natalia, Ashworth, Alan, Irwin, John, Thompson, Michael C., Gestwicki, Jason E., von Delft, Frank, Shoichet, Brian K., Fraser, James S., Ahel, Ivan
Yayımlandı bioRxiv (2020)

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Yazar: Schuller, Marion, Correy, Galen J., Gahbauer, Stefan, Fearon, Daren, Wu, Taiasean, Díaz, Roberto Efraín, Young, Iris D., Carvalho Martins, Luan, Smith, Dominique H., Schulze-Gahmen, Ursula, Owens, Tristan W., Deshpande, Ishan, Merz, Gregory E., Thwin, Aye C., Biel, Justin T., Peters, Jessica K., Moritz, Michelle, Herrera, Nadia, Kratochvil, Huong T., Aimon, Anthony, Bennett, James M., Brandao Neto, Jose, Cohen, Aina E., Dias, Alexandre, Douangamath, Alice, Dunnett, Louise, Fedorov, Oleg, Ferla, Matteo P., Fuchs, Martin R., Gorrie-Stone, Tyler J., Holton, James M., Johnson, Michael G., Krojer, Tobias, Meigs, George, Powell, Ailsa J., Rack, Johannes Gregor Matthias, Rangel, Victor L., Russi, Silvia, Skyner, Rachael E., Smith, Clyde A., Soares, Alexei S., Wierman, Jennifer L., Zhu, Kang, O’Brien, Peter, Jura, Natalia, Ashworth, Alan, Irwin, John J., Thompson, Michael C., Gestwicki, Jason E., von Delft, Frank, Shoichet, Brian K., Fraser, James S., Ahel, Ivan
Yayımlandı Sci Adv (2021)

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

Yazar: Gupta, Meghna, Azumaya, Caleigh M., Moritz, Michelle, Pourmal, Sergei, Diallo, Amy, Merz, Gregory E., Jang, Gwendolyn, Bouhaddou, Mehdi, Fossati, Andrea, Brilot, Axel F., Diwanji, Devan, Hernandez, Evelyn, Herrera, Nadia, Kratochvil, Huong T., Lam, Victor L., Li, Fei, Li, Yang, Nguyen, Henry C., Nowotny, Carlos, Owens, Tristan W., Peters, Jessica K., Rizo, Alexandrea N., Schulze-Gahmen, Ursula, Smith, Amber M., Young, Iris D., Yu, Zanlin, Asarnow, Daniel, Billesbølle, Christian, Campbell, Melody G., Chen, Jen, Chen, Kuei-Ho, Chio, Un Seng, Dickinson, Miles Sasha, Doan, Loan, Jin, Mingliang, Kim, Kate, Li, Junrui, Li, Yen-Li, Linossi, Edmond, Liu, Yanxin, Lo, Megan, Lopez, Jocelyne, Lopez, Kyle E., Mancino, Adamo, Moss, Frank R., Paul, Michael D., Pawar, Komal Ishwar, Pelin, Adrian, Pospiech, Thomas H., Puchades, Cristina, Remesh, Soumya Govinda, Safari, Maliheh, Schaefer, Kaitlin, Sun, Ming, Tabios, Mariano C, Thwin, Aye C., Titus, Erron W., Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Zhang, Kaihua, Zhang, Yang, Zhao, Jianhua, Zhou, Fengbo, Zhou, Yuan, Zuliani-Alvarez, Lorena, Agard, David A, Cheng, Yifan, Fraser, James S, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R., Stroud, Robert M, Swaney, Danielle L, Krogan, Nevan J, Frost, Adam, Rosenberg, Oren S, Verba, Kliment A
Yayımlandı bioRxiv (2021)

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

Yazar: Gupta, Meghna, Azumaya, Caleigh M., Moritz, Michelle, Pourmal, Sergei, Diallo, Amy, Merz, Gregory E., Jang, Gwendolyn, Bouhaddou, Mehdi, Fossati, Andrea, Brilot, Axel F., Diwanji, Devan, Hernandez, Evelyn, Herrera, Nadia, Kratochvil, Huong T., Lam, Victor L., Li, Fei, Li, Yang, Nguyen, Henry C., Nowotny, Carlos, Owens, Tristan W., Peters, Jessica K., Rizo, Alexandrea N., Schulze-Gahmen, Ursula, Smith, Amber M., Young, Iris D., Yu, Zanlin, Asarnow, Daniel, Billesbølle, Christian, Campbell, Melody G., Chen, Jen, Chen, Kuei-Ho, Chio, Un Seng, Dickinson, Miles Sasha, Doan, Loan, Jin, Mingliang, Kim, Kate, Li, Junrui, Li, Yen-Li, Linossi, Edmond, Liu, Yanxin, Lo, Megan, Lopez, Jocelyne, Lopez, Kyle E., Mancino, Adamo, Moss, Frank R., Paul, Michael D., Pawar, Komal Ishwar, Pelin, Adrian, Pospiech, Thomas H., Puchades, Cristina, Remesh, Soumya Govinda, Safari, Maliheh, Schaefer, Kaitlin, Sun, Ming, Tabios, Mariano C, Thwin, Aye C., Titus, Erron W., Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Zhang, Kaihua, Zhang, Yang, Zhao, Jianhua, Zhou, Fengbo, Zhou, Yuan, Zuliani-Alvarez, Lorena, Agard, David A, Cheng, Yifan, Fraser, James S, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R., Stroud, Robert M, Swaney, Danielle L, Krogan, Nevan J, Frost, Adam, Rosenberg, Oren S, Verba, Kliment A
Yayımlandı Res Sq (2021)

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Yazar: Gordon, David E., Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V., Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S., Obernier, Kirsten, Guo, Jeffrey Z., Batra, Jyoti, Kaake, Robyn M., Weckstein, Andrew R., Owens, Tristan W., Gupta, Meghna, Pourmal, Sergei, Titus, Erron W., Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O’Meara, Matthew J., Tummino, Tia A., Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L., Fabius, Jacqueline M., Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M., Naing, Zun Zar Chi, Pulido, Ernst H., Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A., Azumaya, Caleigh M., Billesbølle, Christian, Brilot, Axel F., Campbell, Melody G., Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T., Liu, Yanxin, Merz, Gregory E., Moritz, Michelle, Nguyen, Henry C., Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N., Schulze-Gahmen, Ursula, Smith, Amber M., Sun, Ming, Young, Iris D., Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R., Chen, Jen, Chio, Cynthia M., Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L., Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E., Melo, Arthur A., Moss, Frank R., Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K., Pospiech, Thomas H., Safari, Maliheh, Sangwan, Smriti, Schaefer, Kaitlin, Thomas, Paul V., Thwin, Aye C., Trenker, Raphael, Tse, Eric, Tsui, Tsz Kin Martin, Wang, Feng, Whitis, Natalie, Yu, Zanlin, Zhang, Kaihua, Zhang, Yang, Zhou, Fengbo, Saltzberg, Daniel, Hodder, Anthony J., Shun-Shion, Amber S., Williams, Daniel M., White, Kris M., Rosales, Romel, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Patel, Arvind H., Rihn, Suzannah, Khalid, Mir M., Vallejo-Gracia, Albert, Fozouni, Parinaz, Simoneau, Camille R., Roth, Theodore L., Wu, David, Karim, Mohd Anisul, Ghoussaini, Maya, Dunham, Ian, Berardi, Francesco, Weigang, Sebastian, Chazal, Maxime, Park, Jisoo, Logue, James, McGrath, Marisa, Weston, Stuart, Haupt, Robert, Hastie, C. James, Elliott, Matthew, Brown, Fiona, Burness, Kerry A., Reid, Elaine, Dorward, Mark, Johnson, Clare, Wilkinson, Stuart G., Geyer, Anna, Giesel, Daniel M., Baillie, Carla, Raggett, Samantha, Leech, Hannah, Toth, Rachel, Goodman, Nicola, Keough, Kathleen C., Lind, Abigail L., Klesh, Reyna J., Hemphill, Kafi R., Carlson-Stevermer, Jared, Oki, Jennifer, Holden, Kevin, Maures, Travis, Pollard, Katherine S., Sali, Andrej, Agard, David A., Cheng, Yifan, Fraser, James S., Frost, Adam, Jura, Natalia, Kortemme, Tanja, Manglik, Aashish, Southworth, Daniel R., Stroud, Robert M., Alessi, Dario R., Davies, Paul, Frieman, Matthew B., Ideker, Trey, Abate, Carmen, Jouvenet, Nolwenn, Kochs, Georg, Shoichet, Brian, Ott, Melanie, Palmarini, Massimo, Shokat, Kevan M., García-Sastre, Adolfo, Rassen, Jeremy A., Grosse, Robert, Rosenberg, Oren S., Verba, Kliment A., Basler, Christopher F., Vignuzzi, Marco, Peden, Andrew A., Beltrao, Pedro, Krogan, Nevan J.
Yayımlandı Science (2020)