The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

Eitemau Tebyg

• HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
  gan: Chou, Seemay, et al.
  Cyhoeddwyd: (2013)
• AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
  gan: Schulze-Gahmen, Ursula, et al.
  Cyhoeddwyd: (2014)
• AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation
  gan: Lu, Huasong, et al.
  Cyhoeddwyd: (2014)
• HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription
  gan: He, Nanhai, et al.
  Cyhoeddwyd: (2010)
• Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
  gan: Schulze-Gahmen, Ursula, et al.
  Cyhoeddwyd: (2016)