Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

HIV-1 Tat hijacks the human superelongation complex (SEC) to promote proviral transcription. Here we report the 5.9 Å structure of HIV-1 TAR in complex with HIV-1 Tat and human AFF4, CDK9, and CycT1. The TAR central loop contacts the CycT1 Tat-TAR recognition motif (TRM) and the second Tat Zn(2+)-bi...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Schulze-Gahmen, Ursula, Echeverria, Ignacia, Stjepanovic, Goran, Bai, Yun, Lu, Huasong, Schneidman-Duhovny, Dina, Doudna, Jennifer A, Zhou, Qiang, Sali, Andrej, Hurley, James H
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072841/
https://ncbi.nlm.nih.gov/pubmed/27731797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15910
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