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Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs

The more than 500 protein kinases comprising the human kinome catalyze hundreds of thousands of phosphorylation events to regulate a diversity of cellular functions; however, the extended substrate specificity is still unknown for many of these kinases. We report here a method for quantitatively des...

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Dettagli Bibliografici
Pubblicato in:Anal Chem
Autori principali: Meyer, Nicole O., O’Donoghue, Anthony J., Schulze-Gahmen, Ursula, Ravalin, Matthew, Moss, Steven M., Winter, Michael B., Knudsen, Giselle M., Craik, Charles S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500290/
https://ncbi.nlm.nih.gov/pubmed/28322550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b05002
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