Global Identification of Peptidase Specificity by Multiplex Substrate Profiling

A simple and rapid multiplex substrate profiling method has been developed to reveal the substrate specificity of any endo- or exo-peptidase using LC-MS/MS sequencing. A physicochemically diverse library of peptides was generated by incorporating all combinations of neighbor and near-neighbor amino...

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Auteurs principaux: O’Donoghue, Anthony J., Eroy-Reveles, A. Alegra, Knudsen, Giselle M., Ingram, Jessica, Zhou, Min, Statnekov, Jacob B., Greninger, Alexander L., Hostetter, Daniel R., Qu, Gang, Maltby, David A., Anderson, Marc O., DeRisi, Joseph L., McKerrow, James H., Burlingame, Alma L., Craik, Charles S.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707110/
https://ncbi.nlm.nih.gov/pubmed/23023596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2182
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