Global Identification of Peptidase Specificity by Multiplex Substrate Profiling

A simple and rapid multiplex substrate profiling method has been developed to reveal the substrate specificity of any endo- or exo-peptidase using LC-MS/MS sequencing. A physicochemically diverse library of peptides was generated by incorporating all combinations of neighbor and near-neighbor amino...

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Detaylı Bibliyografya
Asıl Yazarlar: O’Donoghue, Anthony J., Eroy-Reveles, A. Alegra, Knudsen, Giselle M., Ingram, Jessica, Zhou, Min, Statnekov, Jacob B., Greninger, Alexander L., Hostetter, Daniel R., Qu, Gang, Maltby, David A., Anderson, Marc O., DeRisi, Joseph L., McKerrow, James H., Burlingame, Alma L., Craik, Charles S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707110/
https://ncbi.nlm.nih.gov/pubmed/23023596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2182
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