Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

Por Southworth, Daniel R., Agard, David A.
Publicado em 2008

Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex

Por Southworth, Daniel R., Agard, David A.
Publicado em 2011

EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding

Por SHARMA, DIVYA, SOUTHWORTH, DANIEL R., GREEN, RACHEL
Publicado em 2004

Demonstration of the role of the DnaK chaperone system in assembly of 30S ribosomal subunits using a purified in vitro system

Por MAKI, JENNIFER A., SOUTHWORTH, DANIEL R., CULVER, GLORIA M.
Publicado em 2003

Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation

Por Assimon, Victoria A., Southworth, Daniel R., Gestwicki, Jason E.
Publicado no Biochemistry (2015)

pH dependent conformational changes in the bacterial Hsp90 reveal a Grp94-like conformation at pH6 that is highly active for suppression of citrate synthase aggregation

Por Krukenberg, Kristin A., Southworth, Daniel R., Street, Timothy O., Agard, David A.
Publicado em 2009

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

Por Cunningham, Christian N, Southworth, Daniel R, Krukenberg, Kristin A, Agard, David A
Publicado em 2012

Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome

Por Sharma, Divya, Cukras, Anthony R., Rogers, Elizabeth J., Southworth, Daniel R., Green, Rachel
Publicado em 2007

Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide

Por Krukenberg, Kristin A, Böttcher, Ulrike M K, Southworth, Daniel R, Agard, David A
Publicado em 2009

Switch I-dependent allosteric signaling in a G-protein chaperone–B(12) enzyme complex

Por Campanello, Gregory C., Lofgren, Michael, Yokom, Adam L., Southworth, Daniel R., Banerjee, Ruma
Publicado no J Biol Chem (2017)

Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

Por Yokom, Adam L., Morishima, Yoshihiro, Lau, Miranda, Su, Min, Glukhova, Alisa, Osawa, Yoichi, Southworth, Daniel R.
Publicado em 2014

Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum

Por Teixeira, Filipa, Castro, Helena, Cruz, Tânia, Tse, Eric, Koldewey, Philipp, Southworth, Daniel R., Tomás, Ana M., Jakob, Ursula
Publicado no Proc Natl Acad Sci U S A (2015)

A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

Por Rajagopal, Ponni, Tse, Eric, Borst, Andrew J, Delbecq, Scott P, Shi, Lei, Southworth, Daniel R, Klevit, Rachel E
Publicado no eLife (2015)

Spiral architecture of the Hsp104 disaggregase reveals the structural basis for polypeptide translocation

Por Yokom, Adam L., Gates, Stephanie, Jackrel, Meredith E., Mack, Korrie L., Su, Min, Shorter, James, Southworth, Daniel R.
Publicado no Nat Struct Mol Biol (2016)

THE PROTEIN TARGETING FACTOR GET3 FUNCTIONS AS AN ATP-INDEPENDENT CHAPERONE UNDER OXIDATIVE STRESS CONDITIONS

Por Voth, Wilhelm, Schick, Markus, Gates, Stephanie, Li, Sheng, Vilardi, Fabio, Gostimskaya, Irina, Southworth, Daniel R., Schwappach, Blanche, Jakob, Ursula
Publicado em 2014

BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins

Por Rauch, Jennifer N., Tse, Eric, Freilich, Rebecca, Mok, Sue-Ann, Makley, Leah N., Southworth, Daniel R., Gestwicki, Jason E.
Publicado no J Mol Biol (2016)

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

Por Connarn, Jamie N., Assimon, Victoria A., Reed, Rebecca A., Tse, Eric, Southworth, Daniel R., Zuiderweg, Erik R. P., Gestwicki, Jason E., Sun, Duxin
Publicado em 2014

Polyphosphate: A Conserved Modifier of Amyloidogenic Processes

Por Cremers, Claudia M., Knoefler, Daniela, Gates, Stephanie, Martin, Nicholas, Dahl, Jan-Ulrik, Lempart, Justine, Xie, Lihan, Chapman, Matthew R., Galvan, Veronica, Southworth, Daniel R., Jakob, Ursula
Publicado no Mol Cell (2016)

The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex

Por Smith, Matthew C., Scaglione, K. Matthew, Assimon, Victoria A., Patury, Srikanth, Thompson, Andrea D., Dickey, Chad A., Southworth, Daniel R., Paulson, Henry L., Gestwicki, Jason E., Zuiderweg, Erik R.P.
Publicado em 2013

Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1

Por Byers, Christopher E., Barylko, Barbara, Ross, Justin A., Southworth, Daniel R., James, Nicholas G., Taylor, Clinton A., Wang, Lei, Collins, Katie A., Estrada, Armando, Waung, Maggie, Tassin, Tara C., Huber, Kimberly M., Jameson, David.M., Albanesi, Joseph P.
Publicado no Biochim Biophys Acta (2015)