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EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding

Following peptide-bond formation, the mRNA:tRNA complex must be translocated within the ribosomal cavity before the next aminoacyl tRNA can be accommodated in the A site. Previous studies suggested that following peptide-bond formation and prior to EF-G recognition, the tRNAs occupy an intermediate...

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Autors principals: SHARMA, DIVYA, SOUTHWORTH, DANIEL R., GREEN, RACHEL
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2004 by RNA Society 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370522/
https://ncbi.nlm.nih.gov/pubmed/14681589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5148704
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