Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

Nitric-oxide synthase (NOS) is required in mammals to generate NO for regulating blood pressure, synaptic response, and immune defense. NOS is a large homodimer with well characterized reductase and oxygenase domains that coordinate a multistep, interdomain electron transfer mechanism to oxidize l-a...

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Detalhes bibliográficos
Main Authors: Yokom, Adam L., Morishima, Yoshihiro, Lau, Miranda, Su, Min, Glukhova, Alisa, Osawa, Yoichi, Southworth, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059128/
https://ncbi.nlm.nih.gov/pubmed/24737326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564005
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