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Ubiquitination of Neuronal Nitric-oxide Synthase in the Calmodulin-binding Site Triggers Proteasomal Degradation of the Protein

Nitric-oxide synthase, a cytochrome P450-like hemoprotein enzyme, catalyzes the synthesis of nitric oxide, a critical signaling molecule in a variety of physiological processes. Our laboratory has discovered that certain drugs suicide-inactivate neuronal nitric-oxide synthase (nNOS) and lead to the...

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Main Authors: Clapp, Kelly M., Peng, Hwei-Ming, Jenkins, Gary J., Ford, Michael J., Morishima, Yoshihiro, Lau, Miranda, Osawa, Yoichi
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522261/
https://ncbi.nlm.nih.gov/pubmed/23109339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412494
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