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C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination

It is established that suicide inactivation of neuronal nitric-oxide synthase (nNOS) by drugs and other xenobiotics leads to ubiquitination and proteasomal degradation of the enzyme. The exact mechanism is not known, although it is widely thought that the covalent alteration of the active site durin...

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Détails bibliographiques
Auteurs principaux: Clapp, Kelly M., Peng, Hwei-Ming, Morishima, Yoshihiro, Lau, Miranda, Walker, Vyvyca J., Pratt, William B., Osawa, Yoichi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962462/
https://ncbi.nlm.nih.gov/pubmed/20729196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159178
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