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Holoenzyme Structures of Endothelial Nitric Oxide Synthase – an Allosteric Role for Calmodulin in Pivoting the FMN Domain for Electron Transfer*
While the three-dimensional structures of heme- and flavin-binding domains of the NOS isoforms have been determined, the structures of the holoenzymes remained elusive. Application of electron cryo-microscopy and structural modeling of the bovine endothelial nitric oxide synthase (eNOS) holoenzyme p...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4189982/ https://ncbi.nlm.nih.gov/pubmed/25175399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2014.08.006 |
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