THE PROTEIN TARGETING FACTOR GET3 FUNCTIONS AS AN ATP-INDEPENDENT CHAPERONE UNDER OXIDATIVE STRESS CONDITIONS

Exposure of cells to reactive oxygen species (ROS) causes a rapid and significant drop in intracellular ATP-levels. This energy depletion negatively affects ATP-dependent chaperone systems, making ROS-mediated protein unfolding and aggregation a potentially very challenging problem. Here we show tha...

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Main Authors: Voth, Wilhelm, Schick, Markus, Gates, Stephanie, Li, Sheng, Vilardi, Fabio, Gostimskaya, Irina, Southworth, Daniel R., Schwappach, Blanche, Jakob, Ursula
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204210/
https://ncbi.nlm.nih.gov/pubmed/25242142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.017
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