The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

Protein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide repeat (TPR) domain. Hsp90 has been shown to bind PP5 to activate its phosphatase activity. However, the functional implications of binding Hsp70 to PP5 are not yet clear. In this study, we find t...

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Auteurs principaux: Connarn, Jamie N., Assimon, Victoria A., Reed, Rebecca A., Tse, Eric, Southworth, Daniel R., Zuiderweg, Erik R. P., Gestwicki, Jason E., Sun, Duxin
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908423/
https://ncbi.nlm.nih.gov/pubmed/24327656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519421
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