The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

Protein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide repeat (TPR) domain. Hsp90 has been shown to bind PP5 to activate its phosphatase activity. However, the functional implications of binding Hsp70 to PP5 are not yet clear. In this study, we find t...

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Bibliografische gegevens
Hoofdauteurs: Connarn, Jamie N., Assimon, Victoria A., Reed, Rebecca A., Tse, Eric, Southworth, Daniel R., Zuiderweg, Erik R. P., Gestwicki, Jason E., Sun, Duxin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Protein Structure and Folding
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908423/
https://ncbi.nlm.nih.gov/pubmed/24327656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519421
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