Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

Por Rostami‐Hodjegan, Amin
Publicado no Clin Pharmacol Ther (2017)

Biosimulation in biomedical research, health care and drug development

Por Mosekilde, Erik., Sosnovtseva, Olga., Rostami-Hodjegan, Amin.
Publicado em 2012

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Por Tsamandouras, Nikolaos, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado no Br J Clin Pharmacol (2015)

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Por Scotcher, Daniel, Jones, Christopher, Rostami-Hodjegan, Amin, Galetin, Aleksandra
Publicado no Eur J Pharm Sci (2016)

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic M...

Por Doki, Kosuke, Neuhoff, Sibylle, Rostami‐Hodjegan, Amin, Homma, Masato
Publicado no CPT Pharmacometrics Syst Pharmacol (2019)

The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

Por Dickinson, Gemma L, Lennard, Martin S, Tucker, Geoffrey T, Rostami-Hodjegan, Amin
Publicado em 2007

Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

Por Abduljalil, Khaled, Jamei, Masoud, Rostami-Hodjegan, Amin, Johnson, Trevor N.
Publicado em 2014

Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

Por Al Feteisi, Hajar, Achour, Brahim, Barber, Jill, Rostami-Hodjegan, Amin
Publicado no AAPS J (2015)

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug...

Por Olivares-Morales, Andrés, Lennernäs, Hans, Aarons, Leon, Rostami-Hodjegan, Amin
Publicado no AAPS J (2015)

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Por Scotcher, Daniel, Jones, Christopher R., Galetin, Aleksandra, Rostami-Hodjegan, Amin
Publicado no J Pharmacol Exp Ther (2017)

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

Por Margolskee, Alison, Darwich, Adam S., Galetin, Aleksandra, Rostami-Hodjegan, Amin, Aarons, Leon
Publicado no AAPS J (2015)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

Por Chetty, Manoranjenni, Cain, Theresa, Wedagedera, Janak, Rostami-Hodjegan, Amin, Jamei, Masoud
Publicado no Front Pharmacol (2018)

A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

Por Gaohua, Lu, Abduljalil, Khaled, Jamei, Masoud, Johnson, Trevor N, Rostami-Hodjegan, Amin
Publicado em 2012

Quantifying gut wall metabolism: methodology matters

Por Hatley, Oliver J.D., Jones, Christopher R., Galetin, Aleksandra, Rostami‐Hodjegan, Amin
Publicado no Biopharm Drug Dispos (2017)

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors

Por Hatley, Oliver J.D., Jones, Christopher R., Galetin, Aleksandra, Rostami‐Hodjegan, Amin
Publicado no Biopharm Drug Dispos (2017)

Does previous response to clomifene citrate influence the selection of gonadotropin dosage given in subsequent superovulation treatment cycles?

Por Nguyen, Tien Huu, Lennard, Martin S., Ghobadi, Cyrus, Rostami-Hodjegan, Amin, Ledger, William L.
Publicado em 2006

Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

Por Doki, Kosuke, Darwich, Adam S., Achour, Brahim, Tornio, Aleksi, Backman, Janne T., Rostami‐Hodjegan, Amin
Publicado no Br J Clin Pharmacol (2018)

Animal versus human oral drug bioavailability: Do they correlate?

Por Musther, Helen, Olivares-Morales, Andrés, Hatley, Oliver J.D., Liu, Bo, Rostami Hodjegan, Amin
Publicado em 2014

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

Por Ke, Alice Ban, Nallani, Srikanth C, Zhao, Ping, Rostami-Hodjegan, Amin, Unadkat, Jashvant D
Publicado no Br J Clin Pharmacol (2014)

Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site

Por Musther, Helen, Gill, Katherine L., Chetty, Manoranjenni, Rostami-Hodjegan, Amin, Rowland, Malcolm, Jamei, Masoud
Publicado no AAPS J (2015)